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When an issue is resolved in Safe Mode but reoccurs after a normal boot, it typically indicates that the problem is related to elements that are loaded during the standard startup process. Safe Mode operates differently; it loads only the essential system components and disables third-party extensions, startup items, and some caches, which can help to isolate issues related to additional software or configurations that are not essential for the operating system to run.

Checking startup items is fundamental because these items are applications or processes that are set to run automatically when the system boots normally. If a startup item is causing conflicts or instability, it might trigger the same issue outside of Safe Mode. By examining and adjusting these startup items—such as removing or disabling suspicious or unnecessary applications—you can potentially resolve the issue that appears during normal operation.

Other options like network configurations, peripheral connections, and system preferences might contribute to problems, but they are less likely to be the root cause when the issue is absent in Safe Mode. Safe Mode specifically eliminates problems associated with startup applications and processes, underscoring the importance of investigating startup items when issues persist after exiting this mode.